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NEW YORK - Big success for scientific research in the field of regenerative interventions : for the first time a bionic vagina produced in the laboratory with cells of the same patients were implanted in four teenagers between Mexico and the United States.
A long observation shows that the surgery was a complete success and the new vagina is functional. The group of researchers led by Anthony Atala , noted scientist who directs the Wake Forest Baptist Medical Center 's Institute for Regenerative Medicine ( North Carolina ) , describes on ' Lancet ' This work, conducted with success and " monitored long-term ." The four teenagers who received organs vaginal products from its own cells , engineered in the laboratory. "This pilot study is the first to demonstrate that vaginal organs can be constructed in the laboratory and successfully used in humans ," said Atala . An approach that " may represent a new option for patients who have to undergo reconstructive surgery. Moreover, this study is another example of how the strategies of regenerative medicine may be applied to a wide variety of tissues and organs . "
BORN WITHOUT VAGINA The girls featured in this experiment were born with the syndrome of Mayer-Rokitansky-Kuster-Hauser, a rare genetic condition in which the vagina and uterus are poorly developed or absent. But this pioneering treatment could also be useful in patients suffering from tumors or trauma victims and injuries, the researchers explain. The girls were all between 13 and 18 years old at the time of the interventions, which were performed between June 2005 and October 2008. Well, now the data of the annual visits of follow-up show that up to eight years after surgery, the organs function normally.
ORGAN REBUILT " tissue biopsies , MRI and internal examinations showed that the engineered vaginas were similar in appearance and function to the native tissue ," he assured Atlantida Raya - Rivera , a researcher in charge of the Himfg Tissue Engineering Laboratory in Mexico City , where were performed surgeries . In addition, the responses of patients to an ad hoc questionnaire showed that all had normal sexual function after treatment, including the desire , and all related reports without pain. The structures of the bodies have been engineered using epithelial cells and muscle , taken with a small biopsy of the external genitalia of each patient. In a laboratory GMP ( Good Manufacturing Practices) , the cells were extracted from the tissues , expanded and then placed on a biodegradable material , hand-sewn in the shape of the vagina. Each ' -like organ was custom made according to the shape of each patient. About 5-6 weeks after the biopsy , surgeons have created a channel in the basin of the patient and sutured to the vagina bionic reproductive structures . Previous research had shown that , once placed in the body bioartificial these structures , nerves and blood vessels are formed and the cells expand . At the same time , the material that has been the ' scaffolding is absorbed by the body, while the cells gradually replace the scaffold designed by scientists with a new body .
STUDY tests follow up on vaginas engineered in the laboratory showed that the margin between native tissue and bionic parts was indistinguishable . Before you begin a pilot clinical study , Atala 's team has evaluated this approach in mice and rabbits, since the early 90s. Thanks to these studies, scientists have discovered the importance of using human cells to ' scaffold ' specific , made of absorbable materials . Atala 's team has used a similar approach to design parts of the bladder implanted in nine children since 1998 : the scientist has become the first in the world to implant lab -grown organs in humans. The team has also successfully implanted ureters engineered a bunch of kids . The current study , the researchers said, is limited because of its size : it will be important to gain further clinical experience with this technique , for comparison with surgical procedures now known , and bring to light all the advantages and possible limitations . In any case, the factory of the pieces of human body parts is enhanced , with this work , new parts.
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The BIONIC VAGINA ORGASM WORKS PERFECTLY |
